Medline (NASD: MDLN) soars 41% in Nasdaq debut after IPO backed by Blackstone, Carlyle, and Hellman & Friedman, raising $6.26 billion in 2025’s largest offering Medline’s IPO drew strong investor interest, valuing the firm at $46 billion after a 41% stock surge. Generating $977 million in profit on $20.6 billion in revenue, the company’s global manufacturing network limits tariff risks. Its steady, cash-rich model contrasts with typical volatile, high-growth market entrants. (Link)
Cencora (NYSE: COR) (formerly AmerisourceBergen) to acquire majority stake in OneOncology in $5 billion deal, after already holding a minority position, bolstering community oncology network and specialty distribution strategy The deal combines debt financing and an equity rollover to maintain physician autonomy while integrating OneOncology’s nationwide network within Cencora’s platform. The partnership enhances clinical trials, care coordination, and technology access, supporting community-based cancer care. Analysts see the transaction as a strong vote of confidence in oncology’s growth potential. (Link)
BioMarin (NASD: BMRN) to acquire Amicus Therapeutics (NASD: FOLD) for $4.8 billion, expanding rare disease portfolio with Galafold and Pombiliti-Opfolda The acquisition strengthens BioMarin’s rare disease pipeline by adding Amicus’ Galafold and Pombiliti-Opfolda therapies and kidney candidate DMX-200. These assets complement BioMarin’s enzyme replacement treatments and Voxzogo, supporting revenue growth and global expansion. Analysts view the deal as a strategic fit, reflected in BioMarin’s post-announcement stock surge. (Link)
Matt Holt to lead creation of Thoreau, a $30 billion AI‑enabled health‑tech venture combining New Mountain Capital’s Datavant, Swoop, Machinify, Smarter Technologies and Office Ally The deal would combine five healthcare tech companies into one AI-focused platform aimed at cutting medical costs for payers and providers. New Mountain Capital is weighing a structure that returns about 12 billion dollars in cash plus equity and warrants to its investors, exceeding prior portfolio valuations. (Link)
HCAP Partners invests in Puzzle Healthcare to scale post‑acute care coordination platform across U.S. skilled nursing facilities The investment will accelerate Puzzle Healthcare’s expansion of post-acute care coordination services that track patients for 90 days after skilled nursing stays. Operating in 230 facilities across 15 states, Puzzle uses data-driven workflows to reduce readmissions, lower costs, and safeguard providers from Medicare penalties through improved care continuity. (Link)
Medtronic plc (NYSE: MDT) and MiniMed move toward Nasdaq listing with S‑1 filing for diabetes business IPO The S‑1 filing initiates Medtronic’s plan to spin off its Diabetes unit as MiniMed, which intends to trade on Nasdaq under “MMED.” The IPO and potential split‑off structure depend on regulatory approval and market conditions. MiniMed will focus on AI‑enabled insulin delivery and continuous glucose monitoring technologies. (Link)
Philips to acquire SpectraWAVE to advance AI‑enabled intravascular coronary imaging and physiology through HyperVue and X1‑FFR The acquisition integrates SpectraWAVE’s X1‑FFR software, which measures coronary blood flow from angiograms, with its HyperVue imaging platform combining OCT and NIRS to visualize arterial plaque. Philips aims to unify AI-driven imaging and physiology tools to improve stent placement accuracy and standardize coronary disease treatment quality worldwide. (Link)
HealthStream (NASD: HSTM) acquires MissionCare Collective in deal valued up to $40 million to build largest U.S. caregiver career network The deal brings MissionCare Collective’s 5.2‑million caregiver network and platforms like myCNAjobs and CoachUp Care into HealthStream’s hStream ecosystem. It expands workforce solutions to home health and long‑term care providers, addressing caregiver shortages and aging‑population demands through enhanced recruiting, training, and retention tools supported by cash, stock, and earnout terms. (Link)
XOMA Royalty (NASDAQ: XOMA) to acquire Generation Bio (NASDAQ: GBIO) gaining exposure to Moderna collaboration and ctLNP nucleic acid delivery platform The transaction gives Generation Bio shareholders cash and contingent value rights linked to cash reserves, lease savings, and potential revenues from the Moderna partnership and ctLNP platform. Executed through a tender offer and merger, the deal has 15% shareholder support and is expected to close by February 2026. (Link)
Accordion acquires Pinnacle Healthcare Advisors, via its financial sponsors Charlesbank Capital Partners and Motive Partners, to build scaled revenue cycle management platform for health systems and healthcare investors The acquisition merges Pinnacle’s expertise in cash acceleration, AR reduction, and EHR optimization with Accordion’s AI-driven RCM Center of Excellence. The combined platform aims to help health systems tackle margin pressures, payer complexity, and denial rates by improving revenue performance through advanced analytics and integrated operational support. (Link)
INVO Fertility (NASD: IVF) to acquire Indiana clinic Family Beginnings to expand Midwest fertility footprint after $4.0M private placement The acquisition supports INVO Fertility’s U.S. expansion strategy centered on assisted reproductive technology, including INVOcell-based intravaginal culture. Family Beginnings adds a reputable Indiana clinic with $1.2 million in annual revenue and a full fertility service lineup. The $750,000 deal combines cash and preferred stock, with founder Dr. James Donahue remaining as leader. (Link)
Enjoin acquires Paediatric Resource Group to expand paediatric and adult CDI, APR‑DRG and physician advisor solutions for U.S. hospitals The acquisition combines Enjoin’s adult DRG assurance capabilities with PRG’s paediatric and neonatal CDI expertise to create a unified, tech-enabled revenue integrity platform. It enhances support for children’s and acute-care hospitals through utilization review and denials management, expanding nationwide CDI services under 3 Boomerang’s strategic healthcare platform. (Link)
Sentact acquires Performance Health Partners and Vizient Patient Safety Organization to build an integrated, analytics‑driven patient safety and incident reporting platform across U.S. care settings The acquisitions expand Sentact’s patient safety capabilities by integrating Performance Health Partners’ advanced incident management system and the Vizient Patient Safety Organization’s nationwide collaborative. Combined, they enhance data-driven risk analysis, workflow automation, and advisory support to help healthcare providers identify risks, improve safety practices, and elevate clinical outcomes systemwide. (Link)
Prosperous Health acquires Peninsula Health Center to expand integrated outpatient mental health and addiction services across Palos Verdes and the South Bay The merger creates a comprehensive behavioral health network offering detox, outpatient, and long-term therapy within integrated care plans for addiction and mental illness. Combining Prosperous Health’s physician-led model with Peninsula’s accredited programs enhances local access, continuity of care, telehealth services, and collaboration with hospitals and public health partners. (Link)
